TPRM Workflow & Risk Orchestration Manager

Job Description Company Overview Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. Guided by a commitment to patients, scientific excellence, and operational integrity, Vertex brings together deep expertise, collaboration, and innovation to solve some of the most complex challenges in healthcare. Role Summary Vertex is seeking a Manager, TPRM Workflow Risk Orchestration to join the Global Sourcing Procurement organization within the Source-to-Pay (S2P) Center of Excellence . This role is responsible for designing and embedding third-party risk management (TPRM) into the end-to-end S2P lifecycle through workflow orchestration, lifecycle triggers, and execution guardrails. The Manager will ensure that supplier risk identification, assessment, and mitigation are seamlessly integrated across intake, sourcing, contracting, supplier onboarding, and ongoing supplier lifecycle processes. This individual will translate enterprise risk frameworks into practical, scalable workflows that support compliant execution while preserving speed, usability, and a strong internal customer experience. This is a highly cross-functional individual contributor role with significant influence across Sourcing, Legal, Risk, Compliance, Procurement Operations, Analytics, and Digital/IT. The role owns workflow design and execution enablement, while partnering with stakeholders who manage enterprise risk policy and core technology platforms. Key Responsibilities TPRM Workflow Lifecycle Orchestration Design, implement, and maintain end-to-end TPRM workflows aligned to key supplier lifecycle events, including onboarding, contract initiation, renewal, and ongoing monitoring Embed risk assessment, escalation, review, and remediation steps into S2P workflows to support consistent and audit-ready execution Balance strong risk coverage with operational efficiency and a user-friendly experience Trigger-Based Risk Integration Define and operationalize trigger-based models that initiate risk assessments based on supplier criticality, geography, service type, and lifecycle events Integrate TPRM requirements into intake, guided buying, and orchestration tools Ensure alignment of risk workflows across sourcing, contracting, and supplier management processes Supplier Onboarding Master Data Integration Embed TPRM workflows into supplier onboarding and vendor master data processes so that complete and